Dalteparin Sodium
Dalteparin is produced through controlled nitrous acid de-polymerization of sodium heparin from porcine intestinal mucosa. It is composed of strongly acidic sulfated polysaccharide chains with an average molecular weight of 5 000 and about 90% of the material within the range 2 000 to 9 000. Dalteparin is composed of molecules with and without a specially characterized pentasaccharide, the antithrombin binding site, that is essential for high affinity binding to the plasma protein antithrombin (ATIII).
Dalteparin acts antithrombotically mainly by accelerating the rate of the neutralization of certain activated coagulation factors by ATIII but other mechanisms may also be involved. Dalteparin potentiates preferentially the inhibition of coagulation factor Xa and only slightly affects other hemostatic mechanisms such as clotting time and the antithrombotic effect of dalteparin is well correlated to the inhibition of factor Xa.
Ulinastatin is derived from human urine. Physical Appearance :White lyophilized powder.
SPECIFICATION: API
STANDARD: BP/EP